Clinical guidelines are developed to improve the health and safety of patients. While guidelines are informed by the best available evidence and strong quality criteria, it can be challenging to implement them. This guide and toolkit was produced by CES together with the National Clincal Effectiveness Committee (Department of Health) to support health professionals, managers and clinical staff to implement National Clinical Guidelines. The Guide contains a range of tools, which were adapted to meet the needs of staff involved in developing and implementing guidelines and the context in which they work.